Table 4. Association of tagging SNPs of IGFBP1 and IGFBP3 and breast cancer risk in the BPC3.
| SNP | Genotype | Cases (n = 6,912) | Controls (n = 8,891) | OR* (95% CI) | p-trend |
| Block 1 | |||||
| rs10228265 | AA | 3112 | 3962 | 1.00 (ref.) | |
| AG | 2765 | 3637 | 0.98 (0.92–1.04) | ||
| GG | 646 | 846 | 0.98 (0.89–1.08) | 0.54 | |
| rs1553009 | GG | 4273 | 5490 | 1.00 (ref.) | |
| GA | 2046 | 2668 | 0.99 (0.93–1.05) | ||
| AA | 243 | 336 | 0.93 (0.80–1.08) | 0.419 | |
| rs35539615 | CC | 2760 | 4836 | 1.00 (ref.) | |
| CG | 2298 | 3073 | 0.97 (0.92–1.03) | ||
| GG | 389 | 473 | 1.01 (0.90–1.14) | 0.63 | |
| rs2201638 | GG | 6118 | 7831 | 1.00 (ref.) | |
| GA | 497 | 706 | 0.94 (0.85–1.05) | ||
| AA | 34 | 35 | 1.17 (0.81–1.68) | 0.53 | |
| rs1065780 | GG | 2441 | 3083 | 1.00 (ref.) | |
| GA | 2999 | 4080 | 0.95 (0.89–1.01) | ||
| AA | 1055 | 1282 | 1.02 (0.93–1.11) | 0.812 | |
| AGCGG | 1655 | 2070 | 1.00 (ref.) | ||
| AGGGG | 1564 | 2045 | 0.95 (0.90–1.01) | ||
| AACGA | 1263 | 1667 | 0.95 (0.89–1.01) | ||
| GGCGA | 1267 | 1604 | 0.98 (0.92–1.04) | ||
| GGCGG | 555 | 748 | 0.94 (0.87–1.02) | ||
| GGCAG | 255 | 357 | 0.93 (0.83–1.04) | ||
| AGCGA | 52 | 71 | 0.88 (0.69–1.13) | ||
| Haplotype Freq <5% | 112 | 119 | 1.11 (0.94–1.32) | 0.30 | |
| Block 2 | |||||
| rs4988515 | CC | 5933 | 7702 | 1.00 (ref.) | |
| CT | 627 | 782 | 1.00 (0.91–1.11) | ||
| TT | 27 | 33 | 1.06 (0.69–1.63) | 0.86 | |
| rs4619 | AA | 2706 | 3456 | 1.00 (ref.) | |
| AG | 2964 | 3886 | 0.98 (0.92–1.04) | ||
| GG | 907 | 1122 | 1.01 (0.93–1.11) | 0.94 | |
| rs1908751 | CC | 3238 | 4134 | 1.00 (ref.) | |
| CT | 2677 | 3518 | 0.98 (0.92–1.04) | ||
| TT | 593 | 758 | 0.99 (0.89–1.10) | 0.57 | |
| rs2270628 | CC | 4198 | 5472 | 1.00 (ref.) | |
| CT | 2031 | 2606 | 1.00 (0.94–1.06) | ||
| TT | 276 | 629 | 0.99 (0.86–1.14) | 0.93 | |
| CACC | 2274 | 2926 | 1.00 (ref.) | ||
| CATC | 1907 | 2477 | 0.98 (0.94–1.04) | ||
| CGCC | 1198 | 1566 | 0.98 (0.93–1.04) | ||
| CGCT | 901 | 1143 | 1.00 (0.94–1.07) | ||
| TGCT | 348 | 434 | 0.99 (0.91–1.09) | ||
| Haplotype Freq <5% | 95 | 136 | 0.88 (0.73–1.07) | 0.84 | |
| Block 3 | |||||
| rs3110697 | GG | 2241 | 2919 | 1.00 (ref.) | |
| GA | 3032 | 3967 | 1.00 (0.94–1.07) | ||
| AA | 1191 | 1491 | 1.04 (0.95–1.13) | 0.47 | |
| rs2854746 | GG | 2142 | 2759 | 1.00 (ref.) | |
| GC | 2983 | 3843 | 1.01 (0.94–1.08) | ||
| CC | 1208 | 1553 | 1.01 (0.93–1.10) | 0.82 | |
| rs2854744 | GG | 1751 | 2190 | 1.00 (ref.) | |
| GT | 3155 | 4157 | 0.96 (0.90–1.03) | ||
| TT | 1581 | 2011 | 0.98 (0.91–1.07) | 0.69 | |
| GCT | 2778 | 3601 | 1.00 (ref.) | ||
| AGG | 2707 | 3464 | 1.01 (0.97–1.06) | ||
| GGG | 733 | 948 | 1.00 (0.93–1.08) | ||
| GGT | 382 | 513 | 0.95 (0.87–1.05) | ||
| Haplotype Freq <5% | 122 | 155 | 1.03 (0.87–1.22) | 0.80 | |
| Additional SNPs | |||||
| rs6670 | TT | 4210 | 5555 | 1.00 (ref.) | |
| TA | 2022 | 2602 | 1.05 (0.98–1.12) | ||
| AA | 305 | 356 | 1.12 (0.97–1.30) | 0.05 | |
| rs2453839 | TT | 4301 | 5516 | 1.00 (ref.) | |
| TC | 2012 | 2650 | 0.99 (0.93–1.05) | ||
| CC | 274 | 354 | 1.01 (0.87–1.16) | 0.89 | |
| rs2132570 | GG | 3999 | 5182 | 1.00 (ref.) | |
| GT | 2145 | 2772 | 0.99 (0.93–1.06) | ||
| TT | 358 | 441 | 1.01 (0.89–1.15) | 0.99 | |
| rs2960436 | GG | 1795 | 2237 | 1.00 (ref.) | |
| GA | 3127 | 4156 | 0.96 (0.89–1.02) | ||
| AA | 1657 | 2128 | 0.98 (0.90–1.06) | 0.56 |
*
Adjusted for age, race/ethnicity, and country within EPIC cohort