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. 2008 Jul 2;3(7):e2580. doi: 10.1371/journal.pone.0002580

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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Boxes represent the amino acid region of GBV-C NS5A expressed in cloned Jurkat cell lines. Full length NS5A is 414 amino acids in length (1–414). The 126 frame-shift-237 contains GBV-C NS5A sequences that normally encodes these amino acids in the NS5A protein; however, a plus 1 frame shift was introduced so that the cells encode 26 missense amino acids. The amino acid sequence is shown for the 16mer peptide (152–167) and mutant peptides. Shaded boxes indicate cell lines in which HIV replication was inhibited compared to vector controls. Boxes with cross-hatches represent cell lines that inhibited HIV replication compared to controls, but significantly less than those cells indicated by solid shading. * = cell lines described previously.