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. 2008 Jul 2;3(7):e2580. doi: 10.1371/journal.pone.0002580

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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SDF-1 release into culture supernatants was significantly greater in cell lines expressing GBV-C NS5A peptides 152–165, 152–167 and 152–181 compared to the vector control (VC) or frame shift (FS) cell lines after 7 days in culture (* p<0.01 for all; panel A). Jurkat cells expressing full-length NS5A (1–414), the 152–167 peptide and the S158E mutant peptide also induced significantly more SDF-1 than did cells expressing VC, FS or the S158A and S158G peptides (B; * p<0.02 for all on day 7).