Table 2.
Method | m/z | P value (t-test) | P value (LM) | Fold change | AUROC |
MALDI | 1606* | 0.0001 | 0.0006 | 0.72 | 0.71 |
MALDI | 2051* | 0.0253 | 0.0338 | 1.20 | 0.64 |
MALDI | 2195* | 0.0027 | 0.0373 | 0.67 | 0.65 |
MALDI | 2254* | 0.0023 | 0.0030 | 1.24 | 0.69 |
MALDI | 4169* | 0.0074 | 0.0083 | 1.25 | 0.65 |
MALDI | 5011 | 0.0068 | 0.0009 | 1.23 | 0.68 |
MALDI | 5239* | 0.0009 | 0.0002 | 1.31 | 0.68 |
MALDI | 11025* | 0.0186 | 0.0430 | 0.48 | 0.60 |
MALDI | 11400* | 0.0146 | 0.0133 | 0.44 | 0.59 |
MALDI-DS | 2193* | 0.0001 | 0.0001 | 0.53 | 0.70 |
MALDI-DS | 2758* | 0.0029 | 0.0029 | 0.74 | 0.64 |
MALDI-DS | 4758* | 0.0121 | 0.0408 | 0.70 | 0.64 |
MALDI-DS | 5812* | 0.0052 | 0.0070 | 0.59 | 0.63 |
MALDI-DS | 6250 | 0.0426 | 0.0108 | 1.22 | 0.60 |
SELDI | 1885 | 0.0153 | 0.0450 | 1.28 | 0.64 |
SELDI | 6086* | 0.0259 | 0.0050 | 1.14 | 0.61 |
SELDI | 11750* | 0.0019 | 0.0032 | 1.67 | 0.67 |
SELDI | 11960* | 0.0005 | 0.0182 | 1.65 | 0.68 |
SELDI-HR | 39480 | 0.0217 | 0.043 | 0.94 | 0.62 |
SELDI-HR | 53760* | 0.0293 | 0.0150 | 0.98 | 0.64 |
Table 2 shows the m/z ratios, p-values obtained by t-test and multiple linear regression (LM), fold-change (cancer mean intensity/control mean intensity) and area under the receiver operator characteristic curve (AUROC) for all peaks which obtained p < 0.05 in both statistical tests. The peaks that are significant in one or both statistical tests if only the early stage cancers are compared to the non-cancer controls are marked with an asterisk.