Table 1.

Endothelial protein expression in response to chronic shear stress profiles. (see table 3 in the electronic supplementary material for references and full gene names)

category	steady	pulsatile	oscillatory	turbulent	strain
adhesion
ICAM-1	down	down	up	up	up
VCAM-1	down	down	up	up	up
E-selectin	down	?	up	up	up
MCP-1	down	down	up	?	up
PECAM (CD31)	up	up	?	?	?
coagulation
tissue factor	down	down	up	?	up
t-PA	up	up	?	n.s.	up
thrombomodulin	down	down	n.s.	down
PAI-1	down	down	?	n.s.	up
TF pathway inhibitor	up	up	down	?	?
TSP-1	down	down	up	up	up
redox
CYP1A1	up	up	?	?	up
CYP1B1	up	up	?	?	up
Cu/Zn-SOD	up	up	n.s.	n.s.	?
NADPH	n.s.	up	up	?	up
growth
bFGF	n.s.	n.s.	n.s.	n.s.	n.s.
TGFβ1	up	up	up	up	?
VEGF	up	up	down	?	up
vasoactivity
eNOS	up	up	n.s.	n.s.	up
ET-1	down	down	up	down	up
prostacyclin	n.s.	n.s.	?	?	up
extracellular matrix
BMP-4	down	down	up	?	?
MMP-9	n.s.	up	up	?	up
collagen IV	up	up			up
MMP-2	n.s.	up	?	?	up
chemokine
IL-8	down	down	up	up	up
IL-13	down	down	up	up	up
other
Kruppel-like lung factor	up	up	?	?	?
Cxn 43	up	up	down	down	up
CxN 37	up	up	down	down	n.s.