Table 3.
Skeletal events
| Skeletal manifestation | Patients with evidence, n (%) | Occurrence of post-baseline events (month) | ||||
|---|---|---|---|---|---|---|
| At baseline or by history | Post-baseline | 0–12 | >12–24 | >24–36 | >36–48 | |
| Medullary infarction | 12 (36) | 4 (12) | 2 | 2 | 0 | 0 |
| Osteoarticular necrosis | 2 (6) | 5 (15) | 4 | 1 | 0 | 0 |
| Lytic lesions | 12 (36) | 3 (9) | 1 | 2 | 0 | 0 |
| Fractures | ||||||
| Long bone | 1 (3) | 0 | 0 | 0 | 0 | 0 |
| Spinal | 1 (3) | 3 (9) | 0 | 1 | 1 | 1 |
| Bone crisis | 13 (39)a | 3 (9) | 2 | 1 | 0 | 1 |
a
Thirteen patients had a history of bone crisis at any time prior to baseline; at baseline, five of these patients reported having a bone crisis in the past 2 months.