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. 2008 Apr 4;95(2):836–846. doi: 10.1529/biophysj.107.124669
1,2-Dioleoyl-sn-glycerophosphatidylcholine DOPC
2,3-Dioleyloxy-propyl-trimetylammonium chloride DOTAP
Dulbecco's modified Eagle's medium DMEM
Multivalent lipids MVLs
Neutral lipids NLs
Cationic lipids CLs
Coarse-grained CG
Monte Carlo MC
Small angle x-ray scattering SAXS
Transfection efficiency TE
Chemical potential of lipids in free (noncomplexed) neutral membranes μfree
DNA interaxial distance dDNA
Energy difference per unit length of one unit cell of the complex Δ
Free energy F
Free energy gain per neutral lipid added to the complex μcomplexNL)
Inverted hexagonal phase of CL-DNA complexes Inline graphic
Lamellar phase of CL-DNA complexes Inline graphic
Length of the complex parallel to the DNA axis Ly
Length of the complex perpendicular to the DNA axis Lx
Lipid bilayer thickness δL
Average area per lipid a
Equilibrium area per lipid aeq
Distance from the DNA rod located at the end of the unit cell (0 ≤ x < dDNA) x
Local area per lipid a(x)
Local mole fraction of species i (i—NL or MVL) Φi(x)
Mean mole fraction of species i (i—NL or MVL) Φi
Membrane charge density σM
Membrane spacing d
Mole fraction of species i Φi
Number of NLs added to a reference state of the complex N
Thickness of the water/DNA layer δW