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Cartoon of the major active site structure in the LDH/NADH·oxamate complex. The hydrogen bonds between Arg-109 and His-195 with C2=O of substrate is shown as is the salt bridge between Arg-171 and the carboxyl of bound substrate. These interactions are crucial, respectively, for catalysis and for binding. The NADH is shown in a boat conformation bringing HA on its C4 carbon into a pseudoaxial geometry, believed to be important to catalyze hydride transfer of this hydrogen.
