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. 2008 Mar 28;95(2):518–526. doi: 10.1529/biophysj.107.125021

FIGURE 1.

FIGURE 1

A graph that has an arbitrary number of negative loops, as many as the number of nodes in the second layer, but its PF-distance is 1: to avoid negative feedback, it suffices to switch the sign of the single (negative) arrow from the bottom to the top node. All unlabeled arrows are positive.