FIGURE 2.

Representative single T-type Ca²⁺ channel currents and ensemble averages. Capacity- and leak-corrected single-channel currents and the corresponding ensemble currents from a single cell-attached patch elicited with step depolarizations to the indicated potentials (left) in the presence of 20 mM Ca²⁺. Currents shown include 15 ms at the holding potential (−100 mV) and 100 ms at the depolarized potential. Currents were sampled at 20 kHz, filtered at 2 kHz, and then downsampled to 4 kHz offline. For graphical purposes, traces were additionally filtered by adjacently averaging by 3. The seal resistance of the patch was >100 GΩ.