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. 2008 Apr 4;95(2):942–950. doi: 10.1529/biophysj.107.117887

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Variation of upstroke morphology for free wall stimulation in experiment and simulation. (A) Experimental map for point stimulation at the center of the left ventricle. The stimulation site is marked “+”, the dashed line marks a section of the surface that we use for comparison of profiles (see F). (B) Activation sequence for point stimulation experiment (same experiment depicted in A). Black lines are isochrones, spaced 1 ms apart; arrows indicate direction of wave propagation. (C) Simulated map for point stimulation at the center of the left ventricle. (D) Activation sequence for point stimulation simulation; details are as in B. (E) Optical upstrokes from selected locations as marked in A and C. (F) Comparison of profiles from experiment and simulation. Lines along which profiles are taken are marked by dashed black lines in A and C; the stimulation site corresponds to distance = 0.

Inline graphic — Variation of upstroke morphology for free wall stimulation in experiment and simulation. (A) Experimental map for point stimulation at the center of the left ventricle. The stimulation site is marked “+”, the dashed line marks a section of the surface that we use for comparison of profiles (see F). (B) Activation sequence for point stimulation experiment (same experiment depicted in A). Black lines are isochrones, spaced 1 ms apart; arrows indicate direction of wave propagation. (C) Simulated map for point stimulation at the center of the left ventricle. (D) Activation sequence for point stimulation simulation; details are as in B. (E) Optical upstrokes from selected locations as marked in A and C. (F) Comparison of profiles from experiment and simulation. Lines along which profiles are taken are marked by dashed black lines in A and C; the stimulation site corresponds to distance = 0.