Figure 3.

The latency (in seconds) taken to locate the visible platform (Visible Platform), the submerged platform (Submerged Platform), and the submerged platform moved to the diagonally opposite quadrant (Reversal). A trial block is composed of four trials, each beginning from one of four different start locations. (a) Performance of wild-type and mutant 129B6(N3) mice. (b) Performance of wild-type and mutant 129B6(N9) mice. (c) Performance of wild-type and mutant 129B6(N3) and 129B6(N9) mice during the postacquisition and post-reversal probe trials. Presented are the number of crossings over the location where the platform was located during initial acquisition training (solid bar) and during reversal training (hatched bar) as well as the equivalent location in the other two quadrants (open bars). Data are presented as group mean ± SEM. ∗, P < 0.05; ∗∗, P < 0.01 compared with the next highest, nontarget, platform crossing.