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. 2008 Jul 9;3(7):e2595. doi: 10.1371/journal.pone.0002595

Figure 4. Maternal exposure to LPS induces microglial activation at birth and synaptic alterations in the adult offspring.

Figure 4

(A) F4/80 labeling of microglia (arrows) in the hippocampus of P0 born from control (CTL) or LPS-injected dams (matLPS). (B) Quantification of microglial density in the hippocampus at P0. Between 4 and 15 pairs of matched slices were counted per experiment, n = 4 experiments; **p<0.001, two-way ANOVA. Scale bar: 100 µm. (C) Increased ratio of excitatory AMPAR and NMDAR currents in hippocampal slices of adults born to control (CTL) or LPS-injected (matLPS) dams. Left, original traces from individual experiments. Right, averaged data from n = 9 CTL and 10 matLPS experiments; **p<0.02.