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. 2008 Jul 9;3(7):e2595. doi: 10.1371/journal.pone.0002595

Figure 5. Pharmacological activation of microglia during embryonic development induces late synaptic alterations in culture.

Figure 5

(A) Coefficient of variation (CV, see Methods), in basal conditions, of the fluctuations of intracellular calcium concentration, in neurons cultured from pups born from control (CTL) or LPS-injected (matLPS) dams. Averaged data from three independent experiments (>200 neurites recorded/experiment); **p<0.0001 Mann-Whitney t test. (B) Coefficient of variation in the presence of AMPAR antagonist CNQX. Averaged data from three independent experiments (>200 neurites recorded/experiment) **p<0.0001 Mann-Whitney t test.