Table 1.
Protocols for silymarin, selenium, herbal medicines on N-nitrosobis(2-oxopropyl)amine-induced hepatocellular carcinoma in hamsters
| Group | Normal | Vehicle | Bs | Sb | Sil | Sel | Sel+Sb/Bs | Sel(H)+Sb/Bs |
|---|---|---|---|---|---|---|---|---|
| n | 8 | 10 | 20 | 20 | 20 | 20 | 17 | 17 |
| BOP | − | + | + | + | + | + | + | + |
| Bs | − | − | 1 mg/kg | − | − | − | − | − |
| Sb | − | − | − | 1 mg/kg | − | − | − | − |
| Sil | − | − | − | − | 1 mg/kg | − | − | − |
| Sel | − | − | − | − | − | 1 mg/kg | 1 mg/kg | 10 mg/kg |
| Sb/Bs | − | − | − | − | − | − | 1 mg/kg | 1 mg/kg |
BOP, N-nitrosobis(2-oxopropyl)amine, 10 mg/kg; Bs, Bupleurum scorzonerifolfium Willd; Sb, Scutellaria baicalensis Georgi; Sb/Bs, Scutellaria baicalensis Georgi+Bupleurum scorzonerifolfium Willd; Sel, selenium; Sel(H), selenium high dose (10 mg/kg); Sil, silymarin. The experimental groups were defined in detail in ‘Methods’.