Table 2.
Effects of silymarin, selenium, herbal medicines on N-nitrosobis(2-oxopropyl)amine-induced hepatocellular carcinoma in hamsters
| Group | Normal | Vehicle | Bs | Sb | Sil | Sel | Sel+Sb/Bs |
|---|---|---|---|---|---|---|---|
| No | 8 | 10 | 20 | 20 | 20 | 20 | 17 |
| BOP | − | + | + | + | + | + | + |
| Survival rate (%) | 100 | 100 | 75 | 50 | 85 | 95 | 82.4 |
| BW (g) | 178 ± 6 | 109 ± 2# | 97 ± 4*# | 94 ± 4*# | 107 ± 4# | 103 ± 2# | 103 ± 3# |
| ALT | 118 ± 18 | 165 ± 21# | 128 ± 17 | 84 ± 17* | 91 ± 14* | 97 ± 11* | 82 ± 13* |
| AST | 110 ± 13 | 143 ± 10 | 135 ± 13 | 123 ± 15 | 123 ± 8 | 162 ± 12# | 139 ± 14 |
| Creatinine | 0.23 ± 0.03 | 0.43 ± 0.03# | 0.58 ± 0.09*# | 0.48 ± 0.04# | 0.47 ± 0.02# | 0.32 ± 0.05 | 0.40 ± 0.04# |
*
P <0.05 vs. vehicle group (BOP+normal saline)
#
P <0.05 vs. normal group (without BOP treatment)
ALT, alanine transminase; AST, aspartate transaminase; BOP, N-nitrosobis(2-oxopropyl)amine; Bs, Bupleurum scorzonerifolfium Willd; BW, body weight; Sb, Scutellaria baicalensis Georgi; Sb/Bs, Bupleurum scorzonerifolfium Willd+Scutellaria baicalensis Georgi; Sel, selenium; Sil, silymarin. The study was designed eight groups as described in ‘Methods’.