Table 1.
The enriched GO terms for target genes of endo-siRNAs.
| All siRNAs with a putative target | |||
| Biological process | n | Per cent | p-value |
| embryonic development | 534 | 23.9 | 3.6E-44 |
| multicellular organismal process | 729 | 32.7 | 7.3E-42 |
| reproduction | 397 | 17.8 | 2.0E-32 |
| larval development | 321 | 14.4 | 4.3E-24 |
| growth | 388 | 17.4 | 6.1E-24 |
| post-embryonic development | 339 | 15.2 | 7.1E-24 |
| cell division | 100 | 4.5 | 7.9E-23 |
| embryonic cleavage | 68 | 3.0 | 9.4E-16 |
| sexual reproduction | 170 | 7.6 | 2.1E-15 |
| reproductive process | 185 | 8.3 | 1.2E-14 |
| Molecular function | N | Per cent | p-value |
| nucleotide binding | 291 | 13.0 | 1.7E-23 |
| purine nucleotide binding | 245 | 11.0 | 4.5E-16 |
| ribonucleotide binding | 235 | 10.5 | 4.6E-16 |
| ATP binding | 205 | 9.2 | 6.1E-15 |
| adenyl ribonucleotide binding | 205 | 9.2 | 7.6E-15 |
| protein binding | 398 | 17.8 | 9.7E-15 |
| RNA binding | 83 | 3.7 | 8.6E-12 |
| nucleic acid binding | 295 | 13.2 | 6.5E-11 |
| helicase activity | 28 | 1.3 | 1.0E-5 |
| protein serine/threonine kinase activity | 83 | 3.7 | 1.9E-5 |
| 22 nucleotides long siRNAs | |||
| Biological process | N | Per cent | p-value |
| multicellular organismal development | 293 | 33.4 | 1.1E-21 |
| embryonic development ending in birth or egg hatching | 221 | 25.2 | 2.7E-20 |
| reproduction | 170 | 19.4 | 7.5E-16 |
| growth | 161 | 18.4 | 1.1E-10 |
| cell division | 44 | 5.0 | 1.4E-10 |
| 23 nucleotides long siRNAs | |||
| Biological process | N | Per cent | p-value |
| multicellular organismal development | 87 | 25.4 | 1.6E-5 |
| reproduction | 50 | 14.6 | 1.9E-4 |
| anatomical structure development | 34 | 9.9 | 4.9E-4 |
| cell division | 14 | 4.1 | 7.5E-4 |
| cell cycle process | 13 | 3.8 | 1.2E-3 |
| 26 nucleotides long siRNAs | |||
| Biological process | N | Per cent | p-value |
| phosphate metabolic process | 26 | 11.9 | 4.4E-09 |
| biopolymer modification | 27 | 12.3 | 1.7E-07 |
| cellular protein metabolic process | 32 | 14.6 | 1.1E-04 |
| cellular macromolecule metabolic process | 32 | 14.6 | 2.0E-04 |
| biopolymer metabolic process | 38 | 17.4 | 2.4E-04 |
Target gene lists were submitted to DAVID 2.0 as described in methods. The 10 most significant GO categories are shown for all siRNAs with a putative target. The 5 most significant GO categories are presented for the siRNAs according to their length. The lists for siRNAs of all lengths are presented in Additional file 4.