Table 3.

Asymmetric Petasis Reaction with Boronate 6d^a

entry	amine	product	% yieldb	erc
1		17a	81	95:5
2		17b	73	93:7
3		17c	82	97:3
4		17d	80	98.5:1.5
5		17e	94	95:5
6		17f	84	95.5:4.5
7		17g	74	89:11
8		17h	87	97:3
9			81	dr 90:10 (R,R:R,S)
10			89	dr 84:16 (S,R:S,S)

^aReactions were run with 0.25 mmol 6d, 0.25 mmol amine, and 15 mol % catalyst and 3Å molecular sieves in toluene for 36 h under Ar, followed by flash chromatography on silica gel.

^bIsolated yield.

^cDetermined by chiral HPLC analysis.