Skip to main content
. Author manuscript; available in PMC: 2009 Jun 1.
Published in final edited form as: Mol Cancer Res. 2008 May 30;6(6):1052–1058. doi: 10.1158/1541-7786.MCR-07-2126

Figure 6. A novel unidirectional cross talk from IGF-IR to Ob-R in breast cancer.

Figure 6

Our results indicate that the IGF-I and leptin receptors interact in human breast cancer cells. Further, cross talk occurs from IGF-IR to Ob-R such that IGF-I stimulation induces phosphorylation and activation of Ob-R. IGF-IR kinase inhibition blocks IGF-I-mediated Ob-R activation. Cross talk is unidirectional, as leptin does not activate IGF-IR.