TABLE 1.
Structural and functional properties of all the RDEB C7 mutants generated in our laboratory
ND, not determined; T, trimer; M, monomer.
C7 mutants | Trimer formation | Protease stability | Cellular secretion | Cell binding | Cell migration |
---|---|---|---|---|---|
Wild type | T | Resistant | + | + | + |
R2008G | T | Resistant | Reduced | Reduced | ND |
R2049E | T | Sensitive | + | Reduced | Reduced |
R2063W | T | Sensitive | + | Reduced | Reduced |
G2569R | T + M | Sensitive | + | + | + |
G2575R | T + M | Sensitive | + | + | + |
G2749R | T + M | Sensitive | + | + | + |