TABLE 1.

Structural and functional properties of all the RDEB C7 mutants generated in our laboratory

ND, not determined; T, trimer; M, monomer.

C7 mutants	Trimer formation	Protease stability	Cellular secretion	Cell binding	Cell migration
Wild type	T	Resistant	+	+	+
R2008G	T	Resistant	Reduced	Reduced	ND
R2049E	T	Sensitive	+	Reduced	Reduced
R2063W	T	Sensitive	+	Reduced	Reduced
G2569R	T + M	Sensitive	+	+	+
G2575R	T + M	Sensitive	+	+	+
G2749R	T + M	Sensitive	+	+	+