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. 2008 Jun 27;283(26):17838–17845. doi: 10.1074/jbc.M709452200

TABLE 1.

Structural and functional properties of all the RDEB C7 mutants generated in our laboratory

ND, not determined; T, trimer; M, monomer.

C7 mutants Trimer formation Protease stability Cellular secretion Cell binding Cell migration
Wild type T Resistant + + +
R2008G T Resistant Reduced Reduced ND
R2049E T Sensitive + Reduced Reduced
R2063W T Sensitive + Reduced Reduced
G2569R T + M Sensitive + + +
G2575R T + M Sensitive + + +
G2749R T + M Sensitive + + +