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Requirements necessary for internalization via distinct endocytic pathways
| Endocytic pathway | Clathrin-mediated | Caveolae-mediated | Non-caveolar raft-dependent |
|---|---|---|---|
| Dependent on clathrin | × | ||
| Dependent on caveolin | × | ||
| Sensitive to hypertonic sucrose, K+ depletion, and chlorpromazine | × | ||
| Sensitive to cholesterol-perturbing agents i.e. filipin and nystatin | × | × | |
| Dependent on dynamin activity | × | × | |
| Dependent on tyrosine kinase activity | × | × | × |
