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Sequestration of membrane-bound tocopherol by αTTP mutants. A, location of AVED-affected residues relative to the ligand-binding pocket of αTTP. Plotted after Meier et al. ((42) Protein Data Bank code 1OIP). B, time-dependent changes in FRET between NBD-tocopherol and fluorescent liposomes in the presence of wild type (WT), R192H, E141K, H101Q, or R59W variants of αTTP (30 μm active protein). Conditions are as in Fig. 1.
