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. 2008 Jun 27;283(26):18032–18039. doi: 10.1074/jbc.M802274200

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Copyright © 2008, The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 3. — Induction of the Mtb Dos regulon in macrophages is modulated by HO-1. A, HO-1 expression in HO-1^+/+ and HO-1^-/- BMM. BMM were collected from HO-1^-/- and HO-1^+/+ littermates and infected with Mtb. HO-1 protein levels were analyzed using Western blotting. Note that levels of HO-2, the constitutive isoform of HO, are unchanged. U, uninfected; I, infected. B, HO-1-generated CO induces the Mtb Dos regulon. HO-1^-/- and HO-1^+/+ BMM were independently infected with Mtb and RNA isolated from intracellular bacilli. Q-PCR was used to analyze the expression of dosR, hspX, and fdxA (an established “fingerprint” of the Dos regulon). Results are expressed as mean ± S.D. (n = 3 in triplicate).