Figure 5.
Islet cell infiltrate in DR4/164/Rag2o/o TcR transgenic mice. H & E staining on formalin fixed paraffin embedded pancreatic tissue from a 28 week old female DR4/164/Rag2o/o mouse (A). Islets were scored as 0-no infiltrate, 1-less than 33%, 2-less than 66%, or 3-greater than 66%. A summary of islet infiltrate scores for 12 female and 6 male DR4/164/Rag2o/o mice is shown in (B) and (C) respectively. Islets were scored as 0-no infiltrate (white bars), 1-less than 33% (light grey bars), 2-less than 66% (dark grey bars), or 3-greater than 66% (black bars).