Skip to main content
. Author manuscript; available in PMC: 2008 Jun 26.
Published in final edited form as: J Biol Chem. 2007 Jan 2;282(9):6161–6171. doi: 10.1074/jbc.M607661200

Fig. 4.

Fig. 4

Role of mitochondrial respiration in CR and Lat1 over-expression induced replicative life span extension. A, Lat1 requires Cyt1 for life span extension. Life span analysis of the wild type cells, the cyt1Δ mutant, and the cyt1Δ mutant with Lat1-oe cells grown in 2% glucose. WT: BY4742 wild type; Lat1-oe: Lat1 over-expression. One set of representative data is shown. B, 0.5% glucose fails to elicit maximum life span extension in the respiratory deficient cyt1Δ mutant whereas 0.05% confers robust life span extension in this mutant. Life span analysis of the wild type and cyt1Δ cells grown in 2%, 0.5% and 0.05% glucose. The results show mean life span (generations) derived from three independent experiments. Error bars denote standard deviations.