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. Author manuscript; available in PMC: 2009 May 1.
Published in final edited form as: Front Neuroendocrinol. 2007 Oct 15;29(2):219–237. doi: 10.1016/j.yfrne.2007.08.006

Figure 6.

Figure 6

Estrogen may influence signaling through the TrkB receptor by at least three different mechanisms. Estrogen may induce BDNF transcription by classical action of nuclear hormone receptor through an estrogen response element (ERE) in the BDNF promoter. Alternatively, estrogen actions at extranuclear estrogen receptors (ER) may activate signaling pathways leading to phosphorylation of the CREB protein, leading to transcription through a cAMP response element (CRE) in the BDNF promoter. Finally, estrogen activation at extranuclear ERs may transactivate the TrkB receptor, possibly by coupling to G-protein signaling.