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. 2008 Jun 11;7:21. doi: 10.1186/1476-511X-7-21

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Copyright © 2008 Thornton et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Total cholesterol efflux from bile (2a) and feces (2b) collected from control and P-glycoprotein deficient mice (Mdr1a/^-/-/1b^-/-) fed normal fat and high fat diets (Mdr1a/^-/-/1b^-/-genotype is designated "MDR" in all graphs; FVB wild type mouse is designated "WT"). No significant differences in total cholesterol in the bile were observed (n = 8; p > 0.05). However, the Mdr1a/^-/-/1b^-/-genotype was associated with a significant increase in fecal cholesterol concentration (n = 7; p < 0.05). Differing letter designations indicate statistically significant data.