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Hepatic LXRa protein expression in P-glycoprotein deficient mice (Mdr1a/-/-/1b-/-) fed normal and high fat diets. A significant increase in protein expression with both the Mdr1a/-/-/1b-/- genotype and with a high fat diet when compared to wild type animals on a normal fat diet (n = 7; p < 0.05 as noted by asterisk). Placing an Mdr1a/-/-/1b-/-animal on a high fat diet did not result in further upregulation of protein expression.
