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. 2008 Jul 9;3(7):e2583. doi: 10.1371/journal.pone.0002583

Figure 2. Expression of UPF1 and UPF2 in MSI and non-MSI (MSS) primary CRCs relative to matched normal colonic mucosa.

Figure 2

In 25 MSI and 31 MSS CRCs we compared the expression of UPF1 and UPF2 between the tumors and matched normal colonic mucosa by real-time quantitative RT-PCR. In all but 5 cases, over-expression of UPF1 was observed in MSI CRC tumors. Considering all samples, the over-expression of UPF1 in MSI tumors was statistically significant (P = 1.5×10−3; paired t-test). In MSS CRCs, a trend for over-expression of this factor was observed under the same conditions (P = 0.08; paired t-test). In patients with MSI or MSS CRCs, UPF2 was not differentially expressed between tumor and matching normal mucosa (P = 0.56 and P = 0.83, respectively; paired t-test).