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. 2008 Jul 9;3(7):e2583. doi: 10.1371/journal.pone.0002583

Figure 3. Target gene-related mRNA expression according to mutational status in 44 MSI primary CRC.

Figure 3

∂Ct values are indicated relative to the mutational status of each gene in the 44 MSI primary CRCs (wild-type and mutated tumor samples are indicated by white circles and black triangles, respectively). For each gene, medium values of ∂Ct related to wild-type (white arrow) or mutated (black arrow) tumor samples were calculated. For all genes except 3 (CDX2, GRB14, TFDP2), a trend for decay of mutant compared to wild-type mRNAs was observed (∂Ct values are inversely proportional to gene expression). Overall, the data provide evidence for significant decay of PTC-mRNAs compared to wild-type mRNAs in vivo in MSI primary CRCs (P<10−4, student t-test).