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. 2008 Jul 9;3(7):e2583. doi: 10.1371/journal.pone.0002583

Figure 4. Relationship between endogenous UPF1 and UPF2 mRNA expression in MSI CRCs and the number of TILs.

Figure 4

The overall number of CD3ε positive-TILs was significantly related to the endogenous expression of UPF1 and UPF2 in this series of 44 MSI primary CRCs (P<0.01; Wald test). Of interest, while tumor samples in which UPF1 and UPF2 expression was low (below the average) presented with variable rates of CD3ε positive-TILs, tumor samples in which UPF1 and UPF2 expression was high (above the average) were almost always characterized with low CD3 count (poorly immunogenic CRCs). These data make UPF1 and UPF2 specific markers of poor anti-tumor immunity in MSI primary CRCs. CD3 protein immunostaining are presented for 2 MSI primary CRC samples showing either low CD3 count and high UPF1 and UPF2 expression (left) or high CD3 count together with low UPF1 and UPF2 expression (right).