Table 4. Comparison of Area under the Receiver Operating Characteristics Curves (AUROC) for survival endpoints, between FibroTest, ActiTest, ALT and viral load. N = 1074.
Marker | Number of patients | Survival without HBV complications | Survival without HBV death | Overall Survival | |||
AUROC | 95% CI | AUROC | 95% CI | AUROC | 95% CI | ||
FibroTest | 1074 | 0.89 | 0.84–0.93c | 0.95 | 0.91–0.97 d | 0.94 | 0.89–96e |
Non-treated | 428 | 0.99 | 0.89–0.90 | 0.99 | 0.96–0.99 | 0.99 | 0.89–0.99 |
Treated | 646 | 0.82 | 0.75–0.88 | 0.90 | 0.84–0.94 | 0.89 | 0.83–0.93 |
ActiTest | 1074 | 0.77 | 0.69–0.83 | 0.87 | 0.79–0.92 | 0.81 | 0.72–0.87 |
Non-treated | 428 | 0.86 | 0.58–0.96 | 0.91 | 0.57–0.98 | 0.86 | 0.58–0.96 |
Treated | 646 | 0.70 | 0.61–0.77 | 0.83 | 0.73–0.89 | 0.76 | 0.65–0.84 |
ALT | 1074 | 0.53 | 0.46–0.60 | 0.55 | 0.44–0.65 | 0.55 | 0.46–0.63 |
Non-treated | 428 | 0.54 | 0.46–0.62 | 0.57 | 0.48–0.64 | 0.54 | 0.46–0.62 |
Treated | 646 | 0.51 | 0.44–0.58 | 0.54 | 0.42–0.64 | 0.53 | 0.44–0.62 |
Viral load | 1074 | 0.64 | 0.55–0.71 | 0.67 | 0.54–0.76 | 0.63 | 0.52–0.72 |
Non-treated | 428 | 0.57 | 0.30–0.76 | 0.62 | 0.28–0.82 | 0.57 | 0.29–0.76 |
Treated | 646 | 0.61 | 0.51–0.69 | 0.65 | 0.51–0.76 | 0.61 | 0.49–0.71 |
FibroTest AUROC greater than that with ActiTest (p<0.001), ALT (p<0.001), Viral load (p<0.001).
FibroTest AUROC greater than that with ActiTest (p = 0.0009), ALT (p = <0.001), Viral load (p<0.001).
FibroTest AUROC greater than that with ActiTest (p<0.001), ALT (p<0.001), Viral load (p<0.001).