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. 2008 Jul 2;3(7):e2573. doi: 10.1371/journal.pone.0002573

Table 4. Comparison of Area under the Receiver Operating Characteristics Curves (AUROC) for survival endpoints, between FibroTest, ActiTest, ALT and viral load. N = 1074.

Marker Number of patients Survival without HBV complications Survival without HBV death Overall Survival
AUROC 95% CI AUROC 95% CI AUROC 95% CI
FibroTest 1074 0.89 0.84–0.93c 0.95 0.91–0.97 d 0.94 0.89–96e
Non-treated 428 0.99 0.89–0.90 0.99 0.96–0.99 0.99 0.89–0.99
Treated 646 0.82 0.75–0.88 0.90 0.84–0.94 0.89 0.83–0.93
ActiTest 1074 0.77 0.69–0.83 0.87 0.79–0.92 0.81 0.72–0.87
Non-treated 428 0.86 0.58–0.96 0.91 0.57–0.98 0.86 0.58–0.96
Treated 646 0.70 0.61–0.77 0.83 0.73–0.89 0.76 0.65–0.84
ALT 1074 0.53 0.46–0.60 0.55 0.44–0.65 0.55 0.46–0.63
Non-treated 428 0.54 0.46–0.62 0.57 0.48–0.64 0.54 0.46–0.62
Treated 646 0.51 0.44–0.58 0.54 0.42–0.64 0.53 0.44–0.62
Viral load 1074 0.64 0.55–0.71 0.67 0.54–0.76 0.63 0.52–0.72
Non-treated 428 0.57 0.30–0.76 0.62 0.28–0.82 0.57 0.29–0.76
Treated 646 0.61 0.51–0.69 0.65 0.51–0.76 0.61 0.49–0.71
c

FibroTest AUROC greater than that with ActiTest (p<0.001), ALT (p<0.001), Viral load (p<0.001).

d

FibroTest AUROC greater than that with ActiTest (p = 0.0009), ALT (p = <0.001), Viral load (p<0.001).

e

FibroTest AUROC greater than that with ActiTest (p<0.001), ALT (p<0.001), Viral load (p<0.001).