Table 6. Comparison of Area under the Receiver Operating Characteristics Curves (AUROC) for survival endpoints, between FibroTest, ActiTest, ALT, viral load, Pugh score and APRI index. N = 978.

Biomarker	Number of patients	Survival without HBV complications f		Survival without HBV death g		Overall Survival h
	978	AUROC	95% CI	AUROC	95% CI	AUROC	95% CI
FibroTest	978	0.89	0.83–0.93	0.95	0.91–0.97	0.94	0.89–0.96
Non-treated	388	0.98	0.83–0.99	0.99	0.92–0.99	0.98	0.83–0.99
Treated	590	0.82	0.74–0.87	0.90	0.84–0.94	0.89	0.83–0.93
ActiTest	978	0.77	0.69–0.84	0.87	0.79–0.93	0.81	0.72–0.88
Non-treated	388	0.84	0.51–0.95	0.89	0.45–0.98	0.84	0.51–0.95
Treated	590	0.71	0.62–0.79	0.83	0.74–0.89	0.77	0.67–0.85
ALT	978	0.54	0.46–0.62	0.56	0.44–0.66	0.56	0.46–0.65
Non-treated	388	0.62	0.43–0.75	0.67	0.43–0.82	0.62	0.43–0.75
Treated	590	0.52	0.44–0.59	0.54	0.42–0.65	0.54	0.44–0.63
Viral Load	978	0.66	0.57–0.74	0.68	0.55–0.78	0.64	0.53–0.73
Non-treated	388	0.59	0.29–0.78	0.65	0.26–0.86	0.59	0.29–0.78
Treated	590	0.64	0.54–0.72	0.65	0.51–0.76	0.63	0.50–0.73
Pugh classification	978	0.82	0.72–0.89	0.89	0.76–0.95	0.87	0.75–0.93
Non-treated	388	0.92	0.51–0.98	0.97	0.35–0.99	0.92	0.51–0.98
Treated	590	0.79	0.67–0.87	0.86	0.69–0.94	0.84	0.70–0.92
APRI Index	978	0.55	0.49–0.61	0.58	0.49–0.67	0.57	0.49–0.63
Non-treated	388	0.66	0.28–0.86	0.68	0.21–0.89	0.66	0.28–0.86
Treated	590	0.53	0.47–0.58	0.55	0.47–0.63	0.54	0.47–0.60

^fFibroTest AUROC greater than that with ActiTest (p = 0.001), ALT (p<0.001), Viral Load (p<0.001), Pugh classification (p = 0.0025), APRI Index (p<0.001).

^gFibroTest AUROC greater than that with ActiTest (p = 0.0016), ALT (p<0.001), Viral Load (p<0.001), Pugh classification (p = 0.005), APRI Index (p<0.001).

^hFibroTest AUROC greater than that with ActiTest (p<0.001), ALT (p<0.001), Viral Load (p<0.001), Pugh classification (p = 0.002), APRI Index (p<0.001).