Table 8. Survival according to definition of inactive carrier based on FibroTest-ActiTest normal values in untreated patients.
Baseline definition of inactive carrier | N | HBV complications | Survival without HBVcomplications | HBV Related Death | Survival without HBV death | Death | Overall Survival | Overall Survival in paired controls |
All untreated patient | 428 | 8 | 97.4 (95.5–99.2) | 6 | 98.2 (96.8–99.7) | 8 | 97.4 (95.5–99.2) | 99.2 (99.0–99.5) |
Normal FibroTest and ActiTest * | 303 | 0 | 100** | 0 | 100** | 0 | 100** | 99.6 (99.5–99.6) |
Abnormal FibroTest or ActiTest *** | 125 | 8 | 90.8 (84.5–97.1) | 6 | 93.7 (88.8–98.7) | 8 | 90.8 (84.5–97.1) | 98.5 (97.8–99.2) |
Without HIV, HCV, Delta | 397 | 6 | 97.7 (95.8–99.6) | 4 | 98.7 (97.3–99.9) | 6 | 97.7 (95.8–99.6) | 99.2 (99.0–99.5) |
Normal FibroTest and ActiTest | 289 | 0 | 100 | 0 | 100 | 0 | 100 | 99.6 (99.5–99.6) |
Abnormal FibroTest or ActiTest | 108 | 6 | 91.2 (84.2–98.1) | 4 | 94.7 (89.7–99.8) | 6 | 91.2 (84.2–98.1) | 98.4 (97.6–99.1) |
With HIV, HCV, Delta *** | 31 | 2 | 92.8 (83.2–100) | 2 | 92.8 (83.2–100) | 2 | 92.8 (83.2–100) | 99.4 (99.2–99.6) |
Normal FibroTest and ActiTest | 14 | 0 | 100 | 0 | 100 | 0 | 100 | 99.5 (99.2–99.7) |
Abnormal FibroTest or ActiTest | 17 | 2 | 87.5 (71.3–100) | 2 | 87.5 (71.3–100) | 2 | 87.5 (71.3–100) | 99.3 (99.0–99.7) |
Classical Inactive carrier $ | ||||||||
Yes | 275 | 3 | 98.1 (95.9–100) | 1 | 99.5 (98.5–100) | 3 | 98.1 (95.9–100) | 99.1 (98.8–99.4) |
No | 153 | 5 | 95.9 (92.4–99.5) | 5 | 95.9 (92.4–99.5) | 5 | 95.9 (92.4–99.5) | 99.4 (99.2–99.7) |
Both normal values: FibroTest < = 0.27 and ActiTest < = 0.29.
Survivals of patients with abnormal FibroTest and ActiTest were lower than those of normal FibroTest and ActiTest (p<0.005).
Survivals of patients with or without one coinfection (HVI, HCV, Delta) were not significantly different (p>0.05).
Overall survivals of patients with abnormal FibroTest and ActiTest were lower to those in paired controls (p<0.005).
Inactive carrier: anti HBe, normal ALT, viral load <2,000 IU/ml, no coinfection HCV, HIV, or Delta.