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. 2008 Jul 2;3(7):e2573. doi: 10.1371/journal.pone.0002573

Table 8. Survival according to definition of inactive carrier based on FibroTest-ActiTest normal values in untreated patients.

Baseline definition of inactive carrier N HBV complications Survival without HBVcomplications HBV Related Death Survival without HBV death Death Overall Survival Overall Survival in paired controls
All untreated patient 428 8 97.4 (95.5–99.2) 6 98.2 (96.8–99.7) 8 97.4 (95.5–99.2) 99.2 (99.0–99.5)
Normal FibroTest and ActiTest * 303 0 100** 0 100** 0 100** 99.6 (99.5–99.6)
Abnormal FibroTest or ActiTest *** 125 8 90.8 (84.5–97.1) 6 93.7 (88.8–98.7) 8 90.8 (84.5–97.1) 98.5 (97.8–99.2)
Without HIV, HCV, Delta 397 6 97.7 (95.8–99.6) 4 98.7 (97.3–99.9) 6 97.7 (95.8–99.6) 99.2 (99.0–99.5)
 Normal FibroTest and ActiTest 289 0 100 0 100 0 100 99.6 (99.5–99.6)
 Abnormal FibroTest or ActiTest 108 6 91.2 (84.2–98.1) 4 94.7 (89.7–99.8) 6 91.2 (84.2–98.1) 98.4 (97.6–99.1)
With HIV, HCV, Delta *** 31 2 92.8 (83.2–100) 2 92.8 (83.2–100) 2 92.8 (83.2–100) 99.4 (99.2–99.6)
 Normal FibroTest and ActiTest 14 0 100 0 100 0 100 99.5 (99.2–99.7)
 Abnormal FibroTest or ActiTest 17 2 87.5 (71.3–100) 2 87.5 (71.3–100) 2 87.5 (71.3–100) 99.3 (99.0–99.7)
Classical Inactive carrier $
 Yes 275 3 98.1 (95.9–100) 1 99.5 (98.5–100) 3 98.1 (95.9–100) 99.1 (98.8–99.4)
 No 153 5 95.9 (92.4–99.5) 5 95.9 (92.4–99.5) 5 95.9 (92.4–99.5) 99.4 (99.2–99.7)
*

Both normal values: FibroTest < = 0.27 and ActiTest < = 0.29.

**

Survivals of patients with abnormal FibroTest and ActiTest were lower than those of normal FibroTest and ActiTest (p<0.005).

***

Survivals of patients with or without one coinfection (HVI, HCV, Delta) were not significantly different (p>0.05).

****

Overall survivals of patients with abnormal FibroTest and ActiTest were lower to those in paired controls (p<0.005).

$

Inactive carrier: anti HBe, normal ALT, viral load <2,000 IU/ml, no coinfection HCV, HIV, or Delta.