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. 2008 Jul 9;3(7):e2627. doi: 10.1371/journal.pone.0002627

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Nowotny et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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A) The model was fitted to the data, after the transient calcium conductance g_CaT was increased (red) or decreased (black) by 30%. I) Top panel, the evolution of g_CaT and bottom panel the cost function during this re-fitting exercise. During the fit, only g_CaT was allowed to change. II) Same as (I) but g_A was released for fitting (magenta and cyan for up and down change of g_A respectively). III) In addition to g_CaT and g_A, g_KCa was allowed to be fitted (blue and green). B) Parameter and cost function evolution as in (A), while the model was fitted to its own output data. The colors and the panel arrangement are the same as in (A).