Figure 8.

Aspirin inhibition of FMLP- and AA-stimulated neutrophil Erk activity and aggregation is independent of extracellular adenosine release. Neutrophils were incubated for 10 min ± adenosine deaminase (ADA, 3 units/ml), followed by incubation for 10 min ± 10 mM aspirin, stimulation for 2 min with FMLP or AA and measurement of Erk activity (A) or aggregation (B). Results are expressed as percent Erk activity or aggregation relative to neutrophils stimulated in the absence of aspirin and ADA and are the means of two experiments.