Table 1.

IC₅₀s for inhibition of stimulated neutrophil Erk activity and aggregation by salicylates

Stimulus	IC50, mM
	ASA		NaS
	Erk Activity	Aggregation	Erk activity	Aggregation
FMLP (100 nM)	8	3	7	2
AA (20 μM)	2	2	3	1
PMA (1 μg/ml)	N.I.	10	N.I.	N.I.

Neutrophils were incubated for 10 min at 37°C with 0–10 mM ASA or NaS, stimulated with the indicated agents and analyzed for Erk activity or aggregation. 

 N.I., No significant inhibition at the maximum concentration tested.