Table 3.
Markers of immunogenicity for Menjugate recipients. Values in parentheses are 95% confidence intervals
| Marker | Age band (age at blood sampling) | |||
|---|---|---|---|---|
| 11-13 years (n=275) | 14-16 years (n=297) | 17-20 years (n=136) | All ages (n=708) | |
| SBA titre ≥1:8 (%) | 76.4 (70.9 to 81.2)* | 87.5 (83.2 to 91.1) | 88.2 (81.6 to 93.1) | 83.3 (80.4 to 86.0) |
| SBA titre ≥1:128 (%) | 65.1 (59.1 to 70.7)† | 75.1 (69.8 to 79.9) | 77.9 (70.0 to 84.6) | 71.8 (68.3 to 75.0) |
| SBA GMT | 124 (91 to 170)‡ | 312 (236 to 413) | 346 (232 to 516) | 222 (184 to 269) |
| IgG GMC (μg/ml) | 1.1 (0.9 to 1.3)‡ | 2.6 (2.1 to 3.3) | 3.6 (2.6 to 4.9) | 1.9 (1.7 to 2.2) |
GMC=geometric mean concentration; GMT=geometric mean titre; SBA=serum bactericidal antibody.
*P=0.001 for comparison with 14-16 year old age band; P=0.007 for comparison with 17-20 year old age band.
†P=0.02 for comparison with 14-16 year old age band; P=0.02 for comparison with 17-20 year old age band.
‡P<0.0001 for comparisons with14-16 and 17-20 year old age bands.