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. 2008 Jun 24;336(7659):1491–1494. doi: 10.1136/bmj.39570.749884.BE

Table 1.

 Overview of types of quality improvement collaborative and methods in included randomised controlled studies

Study, reference (year) Intervention Methods
Topic, disease, or condition Type of collaborative; length (months) of intervention Study design (control condition) Unit of analysis (project sample size); study sample size Method; No of patients Methodological quality (status)
1, Pierce-Bulger et alw72 (2001) Infant mortality in community Breakthrough Series embedded in longitudinal quality activities (clinic and home visiting services); 12 Interrupted time series (no) Medical centre (NS); 1 (intervention) Chart review; NS Protection from secular changes (not done); data analysed appropriately (NS); reason for points before and after design (NS); shape of intervention effect (NS); protection against bias (NS); blinded assessment (NS); completeness of dataset (NS)
2, Baier et alw61 (2004) Pain Based on Breakthrough Series; 15 Controlled before and after study (no) Nursing homes (21); 15 (intervention), 72 (control) Minimal dataset www.cms.hhs.gov/medicaid/mds20; 276 (intervention) Baseline measurement (no differences); characteristics of control sites (differences); blinded assessment (NS); contamination (unlikely); follow-up sites or teams, 71% intervention, 92% control
3, Benedetti et alw62 (2004) Diabetes in primary care Breakthrough Series, chronic care model; 12-36 Controlled before and after study (no) Providers (NS); 11 (intervention), 19 (control) Method unclear Baseline measurement (not reported); characteristics of control sites (no data, but seemed similar); blinded assessment (NS); contamination (possible); follow-up of sites or teams (NS)
4, Landon et alw63 (2004) HIV Breakthrough Series; 16 Controlled before and after study (no) Clinics (62); 44 (intervention), 25 (control) Review of medical records: 6406 (intervention), 3580 (control) Baseline measurement (no differences); characteristics of control sites (similar); blinded assessment (NS); contamination (unlikely); follow-up of sites or teams (NS)
5, Homer et alw64 (2005) Asthma: children Breakthrough Series, chronic care model; 12 Randomised controlled trial (no) Primary care practice (22); 22 (intervention), 21 (control) Telephone interview: 530 (intervention), 591 (control) Unit of allocation (by practice); randomisation (no process); follow-up of sites (100%); blinded assessment (NS); baseline measurement (no differences); contamination (possible)
6, Mangione-Smith et alw65 (2005) Asthma: children Breakthrough Series, chronic care model; 12 Controlled before and after study (no) Primary care practice (26); 9 (intervention), 4 (control) Review of medical records: 348 (intervention), 153 (control); telephone survey (after study): 385 (intervention), 126 (control) Baseline measurement (possibly different); characteristics of control sites (limited data); blinded assessment (NS); contamination (possible); follow-up of sites or teams (100%):
6, Schonlau et alw66 (2005) Asthma: adults Breakthrough Series, chronic care model; 12 Controlled before and after study (no) Primary care practice (26); 6 (intervention), 3 (control) Review of medical records, 109 (intervention), 76 (control); telephone survey (after study): 123 (intervention), 62 (control) Baseline measurement (possibly different);
characteristics of control sites (limited data); blinded assessment (done); contamination (unlikely); follow-up of sites or teams (100%)
7, Asch et alw67 (2005) Chronic heart failure Breakthrough Series, chronic care model; 12 Controlled before and after study (no) Clinics (14); 4 (intervention), 4 (control): Review of medical records: 261 (intervention), 228 (control); survey (after study): 301 (intervention+control): Baseline measurement (22 of 25 measures similar); characteristics of control sites (limited data); blinded assessment (done); contamination (unlikely); follow-up of sites or teams (100%)
7, Baker et alw68 (2005) Chronic heart failure Breakthrough Series, chronic care model; 12 Controlled cross sectional study (no) Clinics (13); 6 (intervention), 6 (control) Telephone survey (after study): 367 (intervention), 414 (control) Baseline measurement (NA); characteristics of control sites (limited data); blinded assessment (NA); contamination (NA); follow-up of sites or teams (NA)
8, Horbar et alw69 (2001) Preterm infants: infection or chronic lung disease Vermont Oxford Network; 36 Controlled before and after study (feedback in routine reports) Neonatal intensive care units (10); 10 (intervention), 66 (control) Database: 3801 (intervention), 21 509 (control) Baseline measurement (possibly different); characteristics of control sites (limited data); blinded assessment (NS); contamination (unlikely); follow-up of sites or teams (100%)
8, Rogowski et alw70 (2001) Preterm infants: infection or chronic lung disease Vermont Oxford Network; 36 Controlled before and after study (feedback in routine reports) Neonatal intensive care units (10); 10 (intervention), 9 (control) Database on infection: 2993 (intervention), 2203 (control); database on chronic lung disorder 663 (intervention), 1007 (control) Baseline measurement (possibly different); characteristics of control sites (limited data); blinded assessment (NS); contamination (unlikely); follow-up of sites or teams (100%)
9, Horbar et alw71 (2004) Preterm infants: surfactant treatment Vermont Oxford Network; NS Randomised controlled trial (feedback in routine reports) Neonatal intensive care units (57); 57 (intervention), 57 (control) Database: 6645 (intervention), 5576 (control) Unit of allocation (by hospital); randomisation (computer generated); follow-up of sites (100%); blinded assessment (NS); baseline measurement (no differences); contamination (unlikely)

NS=not specified; NA=not applicable.