Fig. 4.

a Liver of pig 3 (¹⁶⁵HoMS): aggregate of microspheres within a hepatic artery with fibrosis and multinucleated giant cells. b Liver of pig 3 (¹⁶⁵HoMS): large portal area with necrosis surrounded by macrophages and multinucleated giant cells and a fibrous capsule with large aggregates of microspheres. c Liver of pig 8 (¹⁶⁶HoMS): a confined moderate-sized aggregate, probably within a hepatic artery, surrounded by hepatic necrosis and hemorrhage of the surrounding parenchyma and partial necrosis of the portal structures. d Stomach of pig 10 (¹⁶⁶HoMS): submucosal artery with microspheres associated with fibrinoid deposition and necrosis of the arterial wall. e Liver of pig 11 (¹⁶⁶HoMS): large area with yellow necrosis and a large aggregate of microspheres within a necrotic hepatic artery. f Gallbladder of pig 16 (¹⁶⁶HoMS): lumen filled with necrotic debris, macrophages, and some neutrophils. Marked fibrosis of the wall with an aggregate of microspheres within an artery