Table 2.
Overview of the pig experiments
| Pig no. | Body weight (kg)a | Administered dosage of HoMS | Absorbed liver dose (Gy)e | Imaging modalities | Termination time (days post-administration) | ||||
|---|---|---|---|---|---|---|---|---|---|
| mgb | MBq | Specific activity (MBq/mg)c | MBq/g liverd | MRI | SPECT | ||||
| 1 | 21.8 | 159 | − | − | − | − | − | − | 30 |
| 2 | 18.0 | 320 | − | − | − | − | − | − | 30 |
| 3 | 18.7 | 430 | − | − | − | − | − | − | 30 |
| 4 | 18.0 | 599 | − | − | − | − | − | − | 30 |
| 5 | 19.4 | 700 | − | − | − | − | + | − | 30 |
| 6 | 21.9 | 294 | 1,786 | 6.1 | 4.1 | 66 (50) | + | + | 30 |
| 7 | 19.0 | 240 | 2,439 | 10.2 | 6.5 | 103 (100) | + | + | 60 |
| 8 | 18.2 | 281 | 4,409 | 15.7 | 6.3 | 101 (150) | − | + | 6 |
| 9 | 19.3 | 221 | 1,410 | 6.4 | 3.7 | 59 (50) | + | + | 60 |
| 10 | 20.0 | 244 | 3,133 | 12.8 | 3.8 | 60 (100) | + | + | 5 |
| 11 | 20.1 | 297 | 2,657 | 8.9 | 6.7 | 107 (100) | + | + | 60 |
| 12 | 19.1 | 278 | 2,846 | 10.2 | 7.6 | 120 (150) | − | + | 20 |
| 13 | 24.5 | 157 | 2,954 | 18.8 | 6.1 | 97 (150) | + | + | 60 |
| 14 | 26.4 | 138 | 3,371 | 24.4 | 6.5 | 103 (150) | + | + | 30 |
| 15 | 29.7 | 170 | 5,825 | 34.3 | 8.3 | 132 (150) | + | + | 53 |
| 16 | 28.8 | 191 | 5,874 | 30.8 | 6.7 | 106 (150) | + | + | 30 |
| 17 | 28.2 | 192 | 6,485 | 33.8 | 10.2 | 162 (150) | − | + | 30 |
| 18 | 29.3 | 223 | 5,895 | 26.4 | 7.4 | 118 (150) | − | + | 60 |
aBody weight at time of administration.
bRegarding the administered amount of microspheres in the non-radioactive experiments (pig no. 1–5) it was assumed that the entire administered dose was selectively deposited in the liver.
cIn the last six experiments specific activity was higher (hence number of microspheres lower) to reduce the risk of backflow.
dAccording to literature (Boxenbaum et al., 1979) the weight of the porcine liver equates to 1.97% of its body weight. The portion of the administered amount of radioactivity actually delivered into the liver was calculated by measuring the 166mHo contents in the ex vivo organs.
eThe organ dose was calculated as follows: [15.87 mJ ∙ MBq-1 ∙ A (MBq)/LW (kg)] × 10–3 (where A is administered amount of radioactivity and LW is liver weight). Intended liver dose is given between parentheses.