Table 2.
Frequency of various HLA-DRB1 and HLA-DQB1 alleles among patients with acute hepatitis E reactive to or non-reactive to HEV ORF2 protein or peptide pools corresponding to this protein
| HEV ORF2 protein |
Pool 2 |
Pool 5 |
Pool 6 |
Pool 8 |
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Locus | Allele | R (n = 32) | NR (n = 8) | R (n = 14) | NR (n = 26) | R (n = 15) | NR (n = 25) | R (n = 17) | NR (n = 23) | R (n = 12) | NR (n = 28) |
| HLA-DRB1 | 010X | 4 | 0 | 2 | 2 | 4 | 0* | 3 | 1 | 1 | 3 |
| 030X | 2 | 3 | 2 | 3 | 0 | 5 | 1 | 4 | 1 | 4 | |
| 040X | 5 | 0 | 2 | 3 | 2 | 3 | 3 | 2 | 1 | 4 | |
| 0701 | 10 | 2 | 5 | 7 | 3 | 9 | 4 | 8 | 4 | 8 | |
| 080X | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | |
| 090X | 1 | 1 | 0 | 2 | 1 | 1 | 1 | 1 | 2 | 0 | |
| 1001 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | |
| 110X | 5 | 0 | 3 | 2 | 1 | 3 | 2 | 3 | 1 | 4 | |
| 120X | 6 | 2 | 2 | 6 | 5 | 3 | 5 | 3 | 2 | 6 | |
| 130X | 8 | 3 | 4 | 7 | 3 | 8 | 3 | 8 | 4 | 7 | |
| 140X | 4 | 0 | 0 | 4 | 3 | 1 | 2 | 2 | 1 | 3 | |
| 150X | 13 | 3 | 7 | 9 | 5 | 11 | 8 | 8 | 5 | 11 | |
| HLA-DQB1 | 0201 | 11 | 4 | 5 | 10 | 4 | 11 | 4 | 11 | 3 | 12 |
| 020X | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | |
| 0301 | 5 | 0 | 2 | 3 | 3 | 2 | 2 | 3 | 2 | 3 | |
| 030X | 10 | 0 | 5 | 5 | 4 | 6 | 6 | 4 | 4 | 6 | |
| 0401 | 2 | 0 | 0 | 2 | 1 | 1 | 0 | 2 | 0 | 2 | |
| 0501 | 4 | 1 | 1 | 4 | 3 | 2 | 3 | 2 | 2 | 3 | |
| 0503 | 1 | 1 | 2 | 0 | 2 | 0 | 2 | 0 | 1 | 1 | |
| 0504 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | |
| 050X | 6 | 2 | 2 | 6 | 3 | 5 | 2 | 6 | 1 | 7 | |
| 0601 | 6 | 1 | 3 | 4 | 2 | 5 | 4 | 2 | 2 | 4 | |
| 0603 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | |
| 060X* | 10 | 4 | 4 | 10 | 4 | 10 | 4 | 10 | 5 | 9 | |
Data are shown as number of patients with a particular HLA allele. R, reactive; NR, nonreactive.
*
P < 0.05 (Yates' corrected chi-square test).