FIGURE 11.
Stimulation of mucin secretion by trypsin. A, effect of trypsin on mucin secretion. Confluent PDEC were treated with 1 μm serosal trypsin for 1 h in Ringer's in the absence (n = 10) or presence of 10 μm La3+ (n = 9). The mucin released into the luminal medium was measured. The relative mucin secretion, normalized to untreated control and averaged, is shown. B, effect of PAR-2 AP and RP on mucin secretion. PDEC were treated with 1 μm concentrations of either serosal PAR-2 AP or serosal PAR-2 RP for 10 min, and the luminal mucin release was measured (n = 3).