A and B, anchorage-independent growth. 20,000 cells were plated in 12-well tissue culture plates. Cell numbers were obtained using a Coulter counter after 11 days. Open bars, cells without Src; closed bars, cells expressing Src. C and D, cell migration assays. 200,000 cells were plated on cell culture inserts (3-µm pore size) in 6-well plates. Cell migration was measured after 72 h as the percent of cells found in the bottom well/total cell number. E, cell migration assays were carried out using 8-µm pore size membranes, and cell migration was examined after 24 h.