Table 7.
Interaction of FKBP5 Genotype and Level of Child Abuse Predicts PTSD Symptoms in Adults
| PTSD Symptom Score, Mean (SEM) | ||||||
|---|---|---|---|---|---|---|
| FKBP5 Genotypes | No. of Participants | No Child Abuse | No. of Participants | 1 Type of Child Abuse | No. of Participants | 2 Types of Child Abuse |
| rs9296158 | ||||||
| AA | 107 | 7.28 (0.93) | 42 | 16.92 (1.85) | 9 | 31.11 (5.37)a |
| AG | 223 | 7.89 (0.69) | 88 | 12.89 (1.16) | 24 | 21.25 (2.03) |
| GG | 107 | 8.80 (1.08) | 31 | 14.33 (2.28) | 14 | 13.54 (3.76) |
| rs3800373 | ||||||
| CC | 89 | 7.03 (0.98) | 35 | 17.65 (2.04) | 8 | 29.00 (5.60)b |
| AC | 210 | 8.11 (0.74) | 77 | 12.71 (1.24) | 23 | 22.96 (2.35) |
| AA | 137 | 7.97 (0.89) | 49 | 15.17 (1.75) | 16 | 13.75 (3.31) |
| rs1360780 | ||||||
| TT | 81 | 7.17 (1.02) | 36 | 16.82 (2.08) | 7 | 31.00 (6.04)b |
| CT | 222 | 7.97 (0.70) | 77 | 13.12 (1.23) | 26 | 21.28 (2.32) |
| CC | 150 | 8.23 (0.87) | 50 | 14.51 (1.73) | 15 | 14.00 (3.53) |
| rs9470080 | ||||||
| TT | 94 | 6.76 (0.99) | 44 | 16.40 (1.84) | 10 | 31.20 (4.69)b |
| CT | 224 | 8.25 (0.69) | 88 | 13.23 (1.17) | 23 | 20.05 (2.26) |
| CC | 109 | 8.42 (1.07) | 28 | 14.90 (2.39) | 13 | 14.38 (3.97) |
Abbreviation: PTSD, posttraumatic stress disorder.
a
Interaction P < .001.
b
Interaction P < .002.