Figure 7. Acquisition and reversal in the Morris water maze task for 3 inbred strains.
Mice were given up to 9 days to reach criterion for learning, set at a group average latency of 15 sec or less to find the hidden platform. The location of the hidden platform was changed to a new quadrant for the reversal task. Only NOD/LtJ (A) met the learning criterion during acquisition, while both NOD/LtJ and PERA/EiJ (C) met criterion during reversal. Data shown are mean (± SEM) of 4 trials per day. 1 mouse from the NOD/LtJ strain died during the reversal phase, leaving a total of 16 subjects in this group.