Table 1.
IL-3 inducible genes downregulated upon STAT5A/B knockdown in Ba/F3-β cells (Affymetrix array data)
| Gene name | Accession no. | 30 min | 2 h | |||
|---|---|---|---|---|---|---|
| Fold up | Fold down | Fold up | Fold down | |||
| (IL-3) | (5AB) | (IL-3) | (5AB) | |||
| 1 | Cytokine inducible SH2-containing protein (Cis)a | NM_009895 | 10.12 | 2.82 | 14.43 | 2.43 |
| 2 | Cytokine inducible SH2-containing protein 1 (Socs-1)a | NM_009896 | 7.91 | 2.74 | 3.66 | 2.23 |
| 3 | Serine (or cysteine) proteinase inhibitor (Spi2.1)a | M64085 | 2.71 | 1.99 | 6.24 | 2.59 |
| 4 | Receptor-like tyrosine kinase (Ryk) | L21707 | 1.25 | 1.01 | 4.25 | 3.44 |
| 5 | Stimulated by retinoic acid 13 (stra13/clast5) | NM_011498 | 3.29 | 2.36 | 5.45 | 2.32 |
| 6 | Schlafen 2 (Sfln2) | NM_011408 | 2.72 | 1.35 | 14.17 | 5.92 |
| 7 | Serine/threonine kinase (Pim-2) | L41495 | 1.41 | 1.31 | 5.04 | 2.07 |
| 8 | Heparin binding epidermal growth factor-like growth factor | NM_010415 | 4.75 | 2.51 | 7.71 | 2.07 |
| 9 | G-protein coupled receptor; anaphylatoxin C3a receptor 1 (C3ar1) | NM_009779 | 1.76 | 2.92 | 2.75 | 3.34 |
| 10 | TNFRSF13b | NM_021349 | 1.41 | 1.46 | 2.19 | 3.25 |
| 11 | Enabled homolog (Drosophila) (enah); Mena; VASP; WASP | NM_010135 | 0.96 | 1.13 | 2.66 | 2.21 |
| 12 | Laminin, alpha 5 (Lama5) | U37501 | 1.08 | 1.22 | 2.60 | 2.01 |
aKnown STAT5 targets from the literature (see text).