Table 3.
Nucleotide sequences of known and newly identified functional STAT5 binding sites (ChIP assay)
| Gene name | Positionb | STAT5 binding site (bold; 5′-3′) (consensus: TTC NNN GAA) | References | |
|---|---|---|---|---|
| 1 | Cisa | (−230/−103) | TTC CTG GAA AG TTC TTG GAA (82) TTC TAG GAA GATGAGGC TTC CGG GAA | (10,48), this study |
| 2 | Socs-3a | (−345/−64) | TTC TTA GAA (241) TTA CAA GAA GACCGGCCGGGCAG TTC CAG GAA | (53), this study |
| 3 | Osma | (−190/−95) | TTC GAA GAA (76) TTC CCA GAA | (93), this study |
| 4 | Spi2.1a | (−127/−92) | TTC CCA GAA ATCACCCGGTCTGTCCAT TTC TCA TTA | (50), this study |
| 5 | IL-2Rαa | (−1268/−1240) | TTC TGA GAA GTACCAGACAT TTC TGA TAA | (35), this study |
| 6 | Id-1a | (+5350/+5710, 4.2 kb downstream gene) | TTC CTG GAA (320) TTC TAT CAA CTGCTCTGAGG TTC CTG CAA | (11), this study |
| 7 | Socs-1a | (−2095/−2061) | TTC AGG GAA CTGAAC TTC CCA GAG CT TTC CCA GAA | This study |
| 8 | MKP-1 | (−3450/−3414) | TTC ACG GAA CACAGGCTCACGGGGTT TTC TTG GAA | This study |
| 9 | TNFRSF13b | (+1662/+1735, intron 2) | TTC TTG GAA (56) TTC TGG GAA | This study |
| 10 | C3ar1 | (−2085/−1520) | TTA GCA GAA (150) TTT CAG GAA (80) TTG GAA AAA AAA TTG GAT GAA (120) … | This study |
| … TTC TTG TAA (20) TTT CTG GAA (130) TTT GAA GAA |
aKnown STAT5 target genes.
bRelative to the transcription start site (except for TNFRSF13b: relative to the translation start site).