Figure 3.

Crystal structure of TSN-64. (A) The ribbon model of TSN-64 bound with four citrate ions. The four domains, SN3, SN4, Tudor and SN5, are rainbow colored from blue (N-terminus) to red (C-terminus). A loop between SN4 and SN5 (residues 635–644) is disordered and is displayed as a dotted line. (B) A schematic diagram representing the domain arrangement in TSN-64. The tudor domain is inserted in SN5 and packed between SN4 and SN5. (C) The electrostatic potential, mapped onto the solvent-accessible surfaces of TSN-64, calculated by APBS (32). The color scale was set from −5 kT/e (red) to +5 kT/e (blue). The molecular surfaces of tudor and SN5 are more acidic, whereas those of SN3 and SN4 are more basic.