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. Author manuscript; available in PMC: 2009 Jun 1.
Published in final edited form as: J Reprod Immunol. 2007 Oct 24;78(1):58–67. doi: 10.1016/j.jri.2007.08.004

Table I.

Passive transfer of polyclonal anti-HSV-2 antibody to B6 or FcγR−/− mice

Incidence a
HSV-2 Shedding b Disease Symptoms c Infection d
Mouse strain Transfer e
B6 PBS 25 \ 25 25 \ 25 25 \ 25
B6 Polyclonal IgG 28 \ 28 17 \ 28 f 28 \ 28
FcγR −/− PBS 15 \ 15 15 \ 15 15 \ 15
FcγR −/− Polyclonal IgG 28 \ 28 25 \ 28 g 28 \ 28
a

Results are expressed as the number of mice exhibiting the indicated outcome per total number of mice. Results are pooled from 2 experiments of identical design.

b

Mice were scored as positive for shedding if infectious virus was detected in the vagina on day 1 or 2 post challenge.

c

Disease symptoms included: erythema, perivaginal hair loss, swelling, and mortality.

d

Mice were considered infected if they shed virus from the vagina on day 1 or 2 post inoculation or developed disease symptoms.

e

Mice received either 50µg of polyclonal anti-HSV-2 antibody or PBS as a control 2 days prior to ivag inoculation of 5×103 PFU HSV-2 strain 186.

f

p<0.0003 compared to PBS-treated control mice, 2-tailed Fisher’s exact test.

g

p< 0.028 compared to Ab-treated B6 mice, 2-tailed Fisher’s exact test.